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Proteins/UNIPROT:Q9Y5I7
Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption..
Function from UniProtKB (Q9Y5I7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
24 statements
24 statements · 4 reference databases · Subject: CLDN16 · Sources: Hetionet, Reactome, Rhea, WikiPathways
7 reactions
3 names
Resolves to: CLDN16
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by TMEM150C or TRPA1 or VDAC1 or GRIA1 or HTR3A or GRIA4 or CLDN10 or NIPAL4 or TMEM63B or NIPAL1 or NIPA1 or PKD1L3 and 17 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29827CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
Transported by KCNK1 or KCNQ3 or KCNQ2 or KCNK2 or CNGA1 or CLDN15 or CLDN2 or KCNK10 or CLDN10 or CNGB1 or CNGA2 or CNGA3 and 8 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78547CC BY 4.0Reference data
Transported by KCNK1 or CNGA1 or GRIA1 or TRPC1 or CLDN15 or CLDN2 or ASIC1 or CLDN10 or CNGB1 or CNGA2 or CNGA3 or ASIC2 and 7 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78551CC BY 4.0Reference data