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Proteins/UNIPROT:Q7Z404

TMC4

Protein·UNIPROT:Q7Z404Voltage-gated chloride channel TMC4

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Voltage-gated chloride channel involved in high-concentration salt taste sensation. Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential. Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride. Involved in pH and temperature-dependent modulation of salty taste..

Function from UniProtKB (Q7Z404), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

2 statements

2 statements · 2 reference databases · Subject: TMC4 · Sources: Hetionet, Rhea

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TMC4 covaries with CLDN16ProteinHetionet hetionet:covaries:10686-147798Inferred only
chloride is transported by TMC4CompoundRhea RHEA:29823Inferred only

Reactions

1 reaction

chloridechloride
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data

Other names

2 names

Resolves to: TMC4

Also called: Transmembrane channel-like protein 4Voltage-gated chloride channel TMC4

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