Proteins/UNIPROT:Q9BUF7

CRB3

ProteinUNIPROT:Q9BUF7

Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)..

Function from UniProtKB (Q9BUF7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: CRB3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CLDN16 covaries with CRB3ProteinHetionet hetionet:covaries:10686-92359Inferred only
PARD6A interacts with CRB3ProteinHetionet hetionet:interacts:50855-92359Inferred only
CRB3 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
CRB3 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
CRB3 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
CRB3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CRB3 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
CRB3 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CRB3 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
CRB3 participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
CRB3 participates in SARS-CoV-2 targets PDZ proteins in cell-cell junctionPathwayReactome R-HSA-9705677Inferred only
CRB3 participates in SARS-CoV-2-host interactionsPathwayReactome R-HSA-9705683Inferred only

Show the remaining 3

CRB3 participates in Tight junction interactionsPathwayReactome R-HSA-420029Inferred only
CRB3 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
CRB3 regulates positive regulation of cell junction assemblyBiological processgene ontology Q9BUF7|GO:1901890Inferred only

Other names

2 names

Resolves to: CRB3

Also called: crumbs homolog 3Protein crumbs homolog 3

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