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Proteins/UNIPROT:Q6UUV7

CRTC3

Protein·UNIPROT:Q6UUV7

Open in the graph

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)..

Function from UniProtKB (Q6UUV7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 3 reference databases · Subject: CRTC3 · Sources: gene ontology, Hetionet, Reactome

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CREB1 interacts with CRTC3ProteinHetionet hetionet:interacts:1385-64784Inferred only
SUMO2 interacts with CRTC3ProteinHetionet hetionet:interacts:64784-6613Inferred only
YWHAG interacts with CRTC3ProteinHetionet hetionet:interacts:64784-7532Inferred only
CRTC3 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
CRTC3 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
CRTC3 participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
CRTC3 participates in Expression of BMAL (ARNTL), CLOCK, and NPAS2PathwayReactome R-HSA-9931509Inferred only
CRTC3 participates in Heme signalingPathwayReactome R-HSA-9707616Inferred only
CRTC3 participates in Mitochondrial biogenesisPathwayReactome R-HSA-1592230Inferred only
CRTC3 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
CRTC3 participates in Transcriptional activation of mitochondrial biogenesisPathwayReactome R-HSA-2151201Inferred only
CRTC3 regulates negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathwayBiological processgene ontology Q6UUV7|GO:0071878Inferred only

Show the remaining 4

CRTC3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q6UUV7|GO:0045944Inferred only
EIF4E increases the expression of CRTC3ProteinHetionet hetionet:regulates:1977-64784Inferred only
IKBKE decreases the expression of CRTC3ProteinHetionet hetionet:regulates:9641-64784Inferred only
PTEN increases the expression of CRTC3ProteinHetionet hetionet:regulates:5728-64784Inferred only

Other names

4 names

Resolves to: CRTC3

Also called: TORC-3TORC3Transducer of CREB protein 3Transducer of regulated cAMP response element-binding protein 3

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