Proteins/UNIPROT:Q9NZU1

FLRT1

ProteinUNIPROT:Q9NZU1

Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3..

Function from UniProtKB (Q9NZU1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spastic paraplegia, optic atropy, and neuropathy has a germline basis in FLRT1DiseaseGenCC HGNC:3760|MONDO:0012297Inferred only

Statements

24 statements

24 statements · 2 reference databases · Subject: FLRT1 · Sources: Hetionet, Reactome

Order

ACTG1 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-71Inferred only
CBLN1 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-869Inferred only
CSNK2B covaries with FLRT1ProteinHetionet hetionet:covaries:1460-23769Inferred only
GNG7 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-2788Inferred only
FLRT1 covaries with HNRNPRProteinHetionet hetionet:covaries:10236-23769Inferred only
HOXC12 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-3228Inferred only
KSR2 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-283455Inferred only
MAP3K3 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-4215Inferred only
MAPRE3 covaries with FLRT1ProteinHetionet hetionet:covaries:22924-23769Inferred only
NRXN2 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-9379Inferred only
NTF3 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-4908Inferred only
OR6B2 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-389090Inferred only

Show the remaining 12

PPP1R9B covaries with FLRT1ProteinHetionet hetionet:covaries:23769-84687Inferred only
PRMT1 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-3276Inferred only
RETREG1 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-54463Inferred only
SH3BP4 covaries with FLRT1ProteinHetionet hetionet:covaries:23677-23769Inferred only
SLC38A12 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-54868Inferred only
TRPM3 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-80036Inferred only
FLRT2 interacts with FLRT1ProteinHetionet hetionet:interacts:23768-23769Inferred only
FLRT1 participates in Downstream signaling of activated FGFR1PathwayReactome R-HSA-5654687Inferred only
FLRT1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FLRT1 participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
FLRT1 participates in Signaling by FGFR1PathwayReactome R-HSA-5654736Inferred only
FLRT1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only

Other names

2 names

Resolves to: FLRT1

Also called: Fibronectin-like domain-containing leucine-rich transmembrane protein 1Leucine-rich repeat transmembrane protein FLRT1

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