Proteins/UNIPROT:O43155

FLRT2

ProteinUNIPROT:O43155

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis..

Function from UniProtKB (O43155), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: FLRT2 · Sources: Hetionet, Reactome

Order

FLRT2 interacts with FLRT1ProteinHetionet hetionet:interacts:23768-23769Inferred only
FLRT2 participates in Downstream signaling of activated FGFR1PathwayReactome R-HSA-5654687Inferred only
FLRT2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FLRT2 participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
FLRT2 participates in Signaling by FGFR1PathwayReactome R-HSA-5654736Inferred only
FLRT2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
AKT1 increases the expression of FLRT2ProteinHetionet hetionet:regulates:207-23768Inferred only

Other names

3 names

Resolves to: FLRT2

Also called: Fibronectin-like domain-containing leucine-rich transmembrane protein 2KIAA0405Leucine-rich repeat transmembrane protein FLRT2

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