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Proteins/UNIPROT:P11597

CETP

Protein·UNIPROT:P11597Cholesteryl ester transfer protein

Open in the graph

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination..

Function from UniProtKB (P11597), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

cholesterol-ester transfer protein deficiency has a germline basis in CETPDiseaseGenCC HGNC:1869|MONDO:0007744Inferred only

Statements

42 statements

42 statements · 5 reference databases · Subject: CETP · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways

Search this listOrder

ARFGEF3 covaries with CETPProteinHetionet hetionet:covaries:1071-57221Inferred only
CETP covaries with CALML3ProteinHetionet hetionet:covaries:1071-810Inferred only
CETP covaries with KIF5BProteinHetionet hetionet:covaries:1071-3799Inferred only
LANCL2 covaries with CETPProteinHetionet hetionet:covaries:1071-55915Inferred only
MAL covaries with CETPProteinHetionet hetionet:covaries:1071-4118Inferred only
MICAL3 covaries with CETPProteinHetionet hetionet:covaries:1071-57553Inferred only
CETP covaries with NUBP1ProteinHetionet hetionet:covaries:1071-4682Inferred only
OLIG3 covaries with CETPProteinHetionet hetionet:covaries:1071-167826Inferred only
CETP covaries with RER1ProteinHetionet hetionet:covaries:1071-11079Inferred only
STXBP5 covaries with CETPProteinHetionet hetionet:covaries:1071-134957Inferred only
TNFAIP3 covaries with CETPProteinHetionet hetionet:covaries:1071-7128Inferred only
UBE2E1 covaries with CETPProteinHetionet hetionet:covaries:1071-7324Inferred only

Show the remaining 30

APOA1 interacts with CETPProteinHetionet hetionet:interacts:1071-335Inferred only
CETP interacts with ARPC3ProteinHetionet hetionet:interacts:10094-1071Inferred only
CETP interacts with EWSR1ProteinHetionet hetionet:interacts:1071-2130Inferred only
CETP interacts with LPLProteinHetionet hetionet:interacts:1071-4023Inferred only
CETP interacts with PRKACGProteinHetionet hetionet:interacts:1071-5568Inferred only
CETP participates in Cholesterol metabolismPathwayWikiPathways WP5304Inferred only
CETP participates in Familial hyperlipidemia type 1PathwayWikiPathways WP5108Inferred only
CETP participates in Familial hyperlipidemia type 2PathwayWikiPathways WP5109Inferred only
CETP participates in Familial hyperlipidemia type 3PathwayWikiPathways WP5110Inferred only
CETP participates in Familial hyperlipidemia type 4PathwayWikiPathways WP5111Inferred only
CETP participates in Familial hyperlipidemia type 5PathwayWikiPathways WP5112Inferred only
CETP participates in HDL remodelingPathwayReactome R-HSA-8964058Inferred only
CETP participates in LDL remodelingPathwayReactome R-HSA-8964041Inferred only
CETP participates in Lipid particles compositionPathwayWikiPathways WP3601Inferred only
CETP participates in Metabolic pathway of LDL HDL and TG including diseasesPathwayWikiPathways WP4522Inferred only
CETP participates in NR1H2 and NR1H3-mediated signalingPathwayReactome R-HSA-9024446Inferred only
CETP participates in NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and effluxPathwayReactome R-HSA-9029569Inferred only
CETP participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
CETP participates in Plasma lipoprotein remodelingPathwayReactome R-HSA-8963899Inferred only
CETP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CETP participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
CETP participates in Statin inhibition of cholesterol productionPathwayWikiPathways WP430Inferred only
CETP participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
CETP regulates negative regulation of macrophage derived foam cell differentiationBiological processgene ontology P11597|GO:0010745Inferred only
CETP regulates positive regulation of cholesterol transportBiological processgene ontology P11597|GO:0032376Inferred only
CETP regulates positive regulation of phospholipid transportBiological processgene ontology P11597|GO:2001140Inferred only
CETP regulates regulation of cholesterol effluxBiological processgene ontology P11597|GO:0010874Inferred only
1,2,3-tri-(9Z-octadecenoyl)-glycerol is transported by CETPCompoundRhea RHEA:43352Inferred only
cholesteryl (9Z-octadecenoate) is transported by CETPCompoundRhea RHEA:43348Inferred only
cholesteryl (9Z,12Z)-octadecadienoate is transported by CETPCompoundRhea RHEA:43356Inferred only

Reactions

3 reactions

cholesteryl (9Z-octadecenoate)cholesteryl (9Z-octadecenoate)
Transported by CETP
Reaction pageDirection not assertedBalanced
Rhea RHEA:43348CC BY 4.0Reference data
1,2,3-tri-(9Z-octadecenoyl)-glycerol1,2,3-tri-(9Z-octadecenoyl)-glycerol
Transported by CETP
Reaction pageDirection not assertedBalanced
Rhea RHEA:43352CC BY 4.0Reference data
cholesteryl (9Z,12Z)-octadecadienoatecholesteryl (9Z,12Z)-octadecadienoate
Transported by

Other names

2 names

Resolves to: CETP

Also called: Cholesteryl ester transfer proteinLipid transfer protein I

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Reaction pageDirection not assertedBalanced

Rhea RHEA:43356CC BY 4.0Reference data