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Proteins/UNIPROT:Q9NSA1

FGF21

Protein·UNIPROT:Q9NSA1

Open in the graph

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity..

Function from UniProtKB (Q9NSA1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

29 statements

29 statements · 4 reference databases · Subject: FGF21 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CDC25A interacts with FGF21ProteinHetionet hetionet:interacts:26291-993Inferred only
CDH7 interacts with FGF21ProteinHetionet hetionet:interacts:1005-26291Inferred only
FGF21 interacts with KLBProteinHetionet hetionet:interacts:152831-26291Inferred only
MAPK7 interacts with FGF21ProteinHetionet hetionet:interacts:26291-5598Inferred only
NEDD4 interacts with FGF21ProteinHetionet hetionet:interacts:26291-4734Inferred only
FGF21 participates in Aryl hydrocarbon receptor response to main mediators PAH and TCDDPathwayWikiPathways WP2586Inferred only
FGF21 participates in Assembly of active LPL and LIPC lipase complexesPathwayReactome R-HSA-8963889Inferred only
FGF21 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
FGF21 participates in Cellular hexose transportPathwayReactome R-HSA-189200Inferred only
FGF21 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only
FGF21 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
FGF21 participates in MAPK signalingPathwayWikiPathways WP382Inferred only

Show the remaining 17

FGF21 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
FGF21 participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
FGF21 participates in Plasma lipoprotein remodelingPathwayReactome R-HSA-8963899Inferred only
FGF21 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
FGF21 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
FGF21 participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
FGF21 participates in Sterol regulatory element binding proteins SREBP signalingPathwayWikiPathways WP1982Inferred only
FGF21 participates in ThermogenesisPathwayWikiPathways WP4321Inferred only
FGF21 participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
FGF21 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
FGF21 regulates positive regulation of cell population proliferationBiological processgene ontology Q9NSA1|GO:0008284Inferred only
FGF21 regulates positive regulation of cold-induced thermogenesisBiological processgene ontology Q9NSA1|GO:0120162Inferred only
FGF21 regulates positive regulation of D-glucose import across plasma membraneBiological processgene ontology Q9NSA1|GO:0046326Inferred only
FGF21 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q9NSA1|GO:0070374Inferred only
FGF21 regulates positive regulation of MAPK cascadeBiological processgene ontology Q9NSA1|GO:0043410Inferred only
FGF21 regulates regulation of cell migrationBiological processgene ontology Q9NSA1|GO:0030334Inferred only
FGF21 regulates regulation of low-density lipoprotein particle clearanceBiological processgene ontology Q9NSA1|GO:0010988Inferred only

Other names

2 names

Resolves to: FGF21

Also called: FGF-21Fibroblast growth factor 21

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