(2E)-tetracosenoyl-CoA

Three steps

• 24-hydroxytetracosanoateReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. tetracosanoate + reduced [NADPH--hemoprotein reductase] + O2 = 24-hydroxytetracosanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 2 morecytosol

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by TECRL, TECR, BAAT, THEM4 and 2 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by TECRL, TECR, BAAT, THEM4 and 4 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by TECRL, TECR, BAAT, THEM4 and 1 morecytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by TECRL, TECR, MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by TECRL, TECR, LPCAT2, LPCAT1cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by TECRL, TECR, LPCAT4cytosol

• undecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 6 morecytosolOne of 3 routes

• 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisome

• O-eicosanoyl-(R)-carnitineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisome

• (5Z)-tetradecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 9 routes

• (3E)-decenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by TECRL, TECR, BAAT, THEM4 and 4 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisome

• N-docosanoylglycineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisome

• an N(2)-acyl-L-glutamineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by TECRL, TECR, GLYATL1B, GLYATL1cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by TECRL, TECR, ACAA1, SCP2 and 2 morecytosol