a 2-acyl-sn-glycero-3-phospho-D-myo-inositol

Three steps

• a triacyl-sn-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by GDPD2, MOGAT2, AWAT2, MOGAT1 and 4 more

• a 1-acyl-sn-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by GDPD2, PLA2G15, ENPP6

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, PLA2G15, TAFAZZIN

• N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by GDPD2, MOGAT2, AWAT2, MOGAT1 and 2 more

• N-hexadecanoylsphinganineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by GDPD2, MOGAT2, AWAT2, MOGAT1 and 2 more

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, MGLL, ABHD6, PLA2G4AOne of 2 routes

• 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by GDPD2, PLA2G15, LPCAT3

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GDPD2, PLA2G15, LPCAT4, LPCAT1

• 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, MGLL, ABHD6, PLA2G4A

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, MGLL, ABHD6, PLA2G4A

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, PLA2G15, PLAAT1

• a 1,3-diacyl-sn-glycerolReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by GDPD2, MGLL, ABHD6, ABHD11

• a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GDPD2, PLA2G15, PLAAT1

• a fatty acyl-CoAReach from here →
  1. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
  2. a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate

  Catalysed by GDPD2, MGLL, ABHD6, ACSL3