4-aminobutanal

Three steps

• L-tryptophanReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by ALDH1A1, ALDH9A1, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• beta-alanineReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by ALDH1A1, ALDH9A1, SLC6A12, SLC6A6 and 1 moreextracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by ALDH1A1, ALDH9A1, SLC6A12, SLC6A14extracellular space, cytosolOne of 5 routes

• L-asparagineReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by ALDH1A1, ALDH9A1, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• L-glutamate 5-semialdehydeReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by ALDH1A1, ALDH9A1, GATM, OAT

• L-phenylalanineReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by ALDH1A1, ALDH9A1, SLC6A12, SLC6A14extracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)

  Catalysed by ALDH1A1, ALDH9A1, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-amino-2-oxopentanoateReach from here →
  1. 4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ALDH1A1, ALDH9A1, GATM, AGXT2One of 2 routes