(3S)-3-hydroxybutanoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

131 compounds within 3 steps: 2 in 1, 5 in 2, 124 in 3

Three steps

(11Z)-eicosenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
nonadecanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Activation of dodecanedioic acid
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1peroxisome, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Production of Sebacoylcarnitine
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Production of Suberylcarnitine
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1peroxisome, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 2 moreperoxisome, cytosolOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 1 moreperoxisome, cytosol
hexadecanedioyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Production of Hexadecanedioylcarnitine
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. fatty-acid-CoA ligase
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 1 moreperoxisome, cytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 6 moreperoxisome, cytosolOne of 3 routes
(5Z)-tetradecenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 4 moreperoxisome, cytosol, mitochondrial matrix
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 3 moreperoxisome, cytosol, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1 and 8 moreperoxisome, cytosolOne of 4 routes