3,7,11,15-tetramethylhexadecanoate

Three steps

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACOT2, CRAT, CROTcytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACOT2, ACAA1, HSD17B4, EHHADH and 1 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACOT2, CPT1A, CPT1C, CPT1Bcytosol, peroxisomeOne of 2 routes

• pristanoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. fatty-acid-CoA ligase

  Catalysed by ACOT2, SLC27A2cytosol, peroxisomeOne of 2 routes

• undecanoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACOT2, ACSM4, ACSM1, ACSM2A and 3 morecytosol, peroxisomeOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACOT2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACOT2, ACADM, ECHS1, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACOT2, HADHA, ACAA2, HADHBcytosol, peroxisome, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACOT2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. phytanate-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACOT2, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 4 routes