hydroxyacetone

Three steps

• (3S)-citramalyl-CoAReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by CYP2E1, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by CYP2E1, AGXT2cytosol

• D-glyceraldehyde 3-phosphateReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. dihydroxyacetone phosphate = methylglyoxal + phosphate
  3. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate

  Catalysed by CYP2E1, TPI1cytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CYP2E1, HOGA1cytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CYP2E1, HOGA1cytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. cytochrome P450 (hydroxyacetone)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CYP2E1, PDHA1, PDHB, PDHA2cytosol, mitochondrial matrix