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Reach

CHEBI:18132

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

225 compounds within 3 steps: 2 in 1, 11 in 2, 212 in 3

Does it reach a compound?

Three steps

pristanoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. fatty-acid-CoA ligase
Catalysed by PHOSPHO1, CHAT, SLC27A2cytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 3 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS1, PTGS2cytosol
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS1, PTGS2cytosol
a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. CTP:choline-phosphate cytidylyltransferase
2. ceramide cholinephosphotransferase (CDP-choline)
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by PCYT1A, PCYT1B, SGMS1, SGMS2cytosol, endoplasmic reticulum
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
thio-Mo-molybdopterinReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by PHOSPHO1, CHDH, MOCOScytosol
(5Z)-tetradecenoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by PHOSPHO1, CHAT, ACADM, ECHS1 and 2 morecytosol, mitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by PHOSPHO1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. Phosphocholine phosphohydrolase
2. Acetyl-CoA:choline O-acetyltransferase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes
prostaglandin H1Reach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS2cytosol
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. Phosphocholine phosphohydrolase
2. choline + A = betaine aldehyde + AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by PHOSPHO1, CHDH, PTGS1, PTGS2cytosol

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