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A reference for what the literature reports. Not medical advice.

Reach

a monoacylglycerol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

351 compounds within 3 steps: 4 in 1, 47 in 2, 300 in 3

Does it reach a compound?

Two steps

tricosanoateReach from here →
1. 1-acylglycerol acylhydrolase
2. (10Z)-heptadecenoic acid formation
Catalysed by ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

Three steps

(S)-carnitineReach from here →
Catalysed by ABHD12, MGLL, ABHD6cytosol, extracellular space, endoplasmic reticulumOne of 260 routes
AReach from here →
Catalysed by ABHD12, and 1 more

Page 2 of 8

MGLL

, ABHD6

, PTGS1

cytosol, extracellular space

One of 11 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 7 morecytosol, extracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 7 morecytosol, extracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP2C8 and 4 morecytosol, extracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 6 morecytosol, extracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP2C9 and 1 morecytosol, extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 5 morecytosol, extracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 25 morecytosol, extracellular spaceOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1 and 25 morecytosol, extracellular spaceOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP1A1cytosol, extracellular space

21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
DHA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate[r]

Catalysed by ABHD12, MGLL, ABHD6, CYP2E1cytosol, extracellular space, endoplasmic reticulumOne of 3 routes

13-hydroxytetradecanoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]

Catalysed by ABHD12, MGLL, ABHD6, CYP2E1cytosol, extracellular space, endoplasmic reticulumOne of 3 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by ABHD12, MGLL, ABHD6, PTGS2cytosol, extracellular space

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by ABHD12, MGLL, ABHD6, PTGS2cytosol, extracellular space

prostaglandin G1Reach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Catalysed by ABHD12, MGLL, ABHD6, PTGS2cytosol, extracellular space

prostaglandin G3Reach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

Catalysed by ABHD12, MGLL, ABHD6, PTGS2cytosol, extracellular space

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABHD12, MGLL, ABHD6, CYP3A4 and 1 morecytosol, extracellular space

(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

Catalysed by ABHD12, MGLL, ABHD6, ALOX5 and 1 morecytosol, extracellular space

14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

Catalysed by ABHD12, MGLL, ABHD6, ALOX15cytosol, extracellular space

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by ABHD12, MGLL, ABHD6, ALOX15cytosol, extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by ABHD12, MGLL, ABHD6, ALOX15cytosol, extracellular space

19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

1-acylglycerol acylhydrolase
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)