N(2)-acetyl-L-ornithine

Three steps

• 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ACY1, ASAH1, PLA2G15cytosol

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by ACY1, ASAH1, PLA2G15cytosol

• 16alpha,17alpha-dihydroxyprogesteroneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACY1, CYP17A1cytosol, endoplasmic reticulum

• 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine

  Catalysed by ACY1, ASAH1, PLA2G15cytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine

  Catalysed by ACY1, ASAH1, PLA2G15cytosol

• thio-Mo-molybdopterinReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by ACY1, SLC7A6, MOCOScytosol, extracellular space

• glycodeoxycholateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by ACY1, GATMcytosolOne of 2 routes

• 1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by ACY1, ASAH1, PLA2G15cytosol

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by ACY1, ASAH1, PLA2G15cytosolOne of 8 routes

• N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by ACY1, ASAH1, CERKcytosol

• N-tetradecanoylglycineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by ACY1, GATM, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by ACY1, GATM, BAATcytosol

• N-docosanoylglycineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ACY1, GATM, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by ACY1, GATM, BAATcytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACY1, SLC7A6, GLYATL1B, GLYATL1cytosol, extracellular space

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space, mitochondrial matrix