androst-4-ene-3,17-dione

Three steps

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. cytochrome P450 (17alpha-hydroxyprogesterone)
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by CYP17A1, DERAendoplasmic reticulum

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. cytochrome P450 (4-androstene-3,17-dione)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. testosterone:NADP+ 17-oxidoreductase
  2. cytochrome P450 (testosterone)
  3. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)

  Catalysed by HSD17B6, HSD17B1, HSD17B3, HSD17B2 and 10 morecytosol, endoplasmic reticulum

• 16beta,17beta-estriolReach from here →
  1. testosterone:NADP+ 17-oxidoreductase
  2. cytochrome P450 (testosterone)
  3. 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 16beta,17beta-estriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by HSD17B6, HSD17B1, HSD17B3, HSD17B2 and 6 morecytosol, endoplasmic reticulum

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. cytochrome P450 (4-androstene-3,17-dione)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 5 moreendoplasmic reticulum, extracellular space, cytosol, mitochondrial matrix