N-(9Z-octadecenoyl)glycine

Three steps

• (5Z)-tetradecenoyl-CoAReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by FAAH, PM20D1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• O-(9Z)-octadecenoyl-(R)-carnitineReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA

  Catalysed by FAAH, PM20D1, SLC27A2, ACSL3 and 7 more

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. Utilized Transport
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by FAAH, PM20D1, CRAT, CROTendoplasmic reticulum, cytosol, peroxisomeOne of 5 routes

• (3E)-decenoyl-CoAReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by FAAH, PM20D1, BAAT, ACADM and 3 moreperoxisome, mitochondrial matrix

• 1-decanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
  3. 1-decanoylglycerol + (9Z)-octadecenoyl-CoA = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by FAAH, PM20D1, SLC27A2, ACSL3 and 7 more

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by FAAH, PM20D1, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by FAAH, PM20D1, SLC7A5, GLYATL1B and 1 moreextracellular space, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by FAAH, PM20D1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• 3-methylmalateReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by FAAH, PM20D1, AADAT, CLYBL

• tricosanoyl-CoAReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by FAAH, PM20D1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 4 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by FAAH, PM20D1, GSS, PTGES and 5 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by FAAH, PM20D1, GSS, GPX1 and 1 more

• thromboxane B2Reach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by FAAH, PM20D1, GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by FAAH, PM20D1, GSS, GSTT4 and 22 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by FAAH, PM20D1, GSS, GPX1 and 3 more

• taurochenodeoxycholateReach from here →
  1. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by FAAH, PM20D1, GSS, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 3 routes