aspartame/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Increases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In our chronic in vivo model, we found that compared with the controls, serum TNF-α was increased in both chow + ASP and HFD + ASP groups (1622.3 ± 184.1 pg/mg of protein and 2512.1 ± 251.4 pg/mg of protein, respectively), indicating a higher level of systemic inflammation in groups receiving ASP.”
Quoted verbatim from Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- 0.96 mg/mL aspartame in drinking water
- Population
- Male C57BL/6 mice on chow or high-fat diet, aspartame in drinking water versus plain water for 18 weeks; serum collected at sacrifice
Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.2017PMID:27997218Permalink
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To cite this finding: https://catalystproject.ai/e/01M45ZC79ZZ9FXSM94AVFYSAKP