knowpeptidesaspartame
Specimen peptide organic compoundPlate I
Aspartame
Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.”
432 readings, by contour and atom
- Formula
- C14H18N2O5
- Molar mass
- 294.307 g/mol
- ChEBI
- CHEBI:2877
- PubChem CID
- 134601
- MeSH
- D001218
- InChIKey
- IAOZJIPTCAWIRG-QWRGUYRKSA-N
↑ raised 5 findings in 5 endpoints · – no difference found 2 in 2
- Strongest evidence
- Very limited4 findings at this level
01 · the evidence, ordered
What the evidence says
- Strong
- 0
- Moderate
- 0
- Limited
- 0
- Very limited
- 4
- Insufficient
- 5
Aspartame
Most findings
- Total cholesterol (TC)×2
- ALPI×1
- Body mass×1
- Tumour necrosis factor alpha concentration×1
Show the remaining 4Show the first 4
- CAT×1
- Fasting blood glucose×1
- LDL cholesterol×1
- Triglycerides×1
36 compounds on the outer ring, not drawn
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- Total cholesterol (TC)contested
- Body mass
- Inhibits ALPI
- Tumour necrosis factor alpha concentration
- Activates CAT
- Fasting blood glucose
- LDL cholesterol
- Triglycerides
02 · contested · 1 endpoint
Where the findings disagree
012 findings
Total cholesterol (TC)
03 · findings
What aspartame moved, and by how much
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
9 shown
- Body massMoved: no difference foundEvidence: Very limitedPaper: PMID 283946432018
- Who
- adults, pooled randomized clinical trials
- Dose studied
- not reported
Body weight did not change after aspartame consumption compared to control (5.00 kg; 95% CI, -1.56 to 11.56) or to sucrose (3.78 kg; 95% CI, -2.18 to 9.74).”
Quoted verbatim from Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials.meta-analysisPermalink - Tumour necrosis factor alpha concentrationMoved: raisesEvidence: Very limitedPaper: PMID 279972182017
- Who
- Male C57BL/6 mice on chow or high-fat diet, aspartame in drinking water versus plain water for 18 weeks; serum collected at sacrifice
- Dose studied
- 0.96 mg/mL aspartame in drinking water
In our chronic in vivo model, we found that compared with the controls, serum TNF-α was increased in both chow + ASP and HFD + ASP groups (1622.3 ± 184.1 pg/mg of protein and 2512.1 ± 251.4 pg/mg of protein, respectively), indicating a higher level of systemic inflammation in groups receiving ASP.”
Quoted verbatim from Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.animal · not in humans · 4 monthsPermalink - ALPIMoved: inhibitsEvidence: Very limitedPaper: PMID 279972182017
- Who
- Male mice, isolated 6-cm small-bowel loop injected with aspartame solution or saline, luminal contents assayed after 3 h
- Dose studied
- 34 mg/kg instilled into the bowel loop
In the bowel loop model, IAP activity was significantly (p = 0.02) reduced in mice that had ASP instilled into the loops compared with saline controls (0.2 ± 0.03 vs 0.4 ± 0.24).”
Quoted verbatim from Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.animal · not in humansPermalink - Total cholesterol (TC)contestedMoved: no difference foundEvidence: Very limitedPaper: PMID 283946432018
- Who
- adults, pooled randomized clinical trials
- Dose studied
- not reported
Total cholesterol was not affected by aspartame consumption compared to control (-0.02 mmol/L; 95% CI, -0.31 to 0.27) or to sucrose (-0.24 mmol/L; 95% CI, -0.89 to 0.42).”
Quoted verbatim from Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials.meta-analysisPermalink - TriglyceridesMoved: raisesEvidence: InsufficientPaper: PMID 262475072016
- Who
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
- Dose studied
- 35 and 70 mg/kg daily by oral gavage
Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.animal · not in humans · 2 monthsPermalink - Total cholesterol (TC)contestedMoved: raisesEvidence: InsufficientPaper: PMID 262475072016
- Who
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
- Dose studied
- 35 and 70 mg/kg daily by oral gavage
Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.animal · not in humans · 2 monthsPermalink - LDL cholesterolMoved: raisesEvidence: InsufficientPaper: PMID 262475072016
- Who
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
- Dose studied
- 35 and 70 mg/kg daily by oral gavage
Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.animal · not in humans · 2 monthsPermalink - Fasting blood glucoseMoved: raisesEvidence: InsufficientPaper: PMID 344205382022
- Who
- Male Sprague Dawley rats, 7 weeks of age at start; three aspartame arms (0.05% in diet, in drinking water, or both) pooled against an unsweetened-diet, plain-water control, 7 weeks, overnight fasted at termination
- Dose studied
- 0.05% aspartame w/w in diet and/or drinking water
At the blood metabolites level, fasting plasma glucose was significantly higher among the aspartame groups (P = 0·003) and this seems to relate to the amount of ingested aspartame (r = 0·585, P = 0·001) (Table 2).”
Quoted verbatim from The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.animal · not in humans · 7 weeksPermalink - CATMoved: activatesEvidence: InsufficientPaper: PMID 250097842014
- Who
- Male Wistar rats given methotrexate; aspartame-plus-methotrexate group versus saline control and methotrexate-only control; six brain regions, tissue assay
- Dose studied
- not reported
The activity of catalase was increased markedly in all the regions of brain (cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)) in aspartame treated MTX animals with respect to control and MTX treated control.”
Quoted verbatim from Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain.animal · not in humansPermalink
No row matches these filters.
No dose is advised.
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
04 · identity
Structure
- Charge
- 0
- SMILES
- COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
05 · figures · 2 plates
Plates
fig. 6Aspartame · electrostatic potential, molecular plane · PubChem CID 134601, computed 3D conformer 
fig. 7Aspartame · MS2 [M+H]+ LC-ESI-ITFT positive · MassBank MSBNK-Eawag-EA277009 (Stravs M, CC BY)
What the reference databases state
- Trials · ClinicalTrials.gov
- 47registered without posted results · 46 past the reporting window
47Registered trials without posted results
Registered, and not reported
- Source
- ClinicalTrials.gov
- Intervention
- aspartame
- Status
- Completed, terminated or suspended
- Results posted
- No
Trials without posted results
47 trials
47 registered trials without posted results · Overdue (FDAAA 801): 46
46 past the window1 within it, or no actual date
- NCT04567108completed2026-05-21a university or hospital
- NCT07764367completed2025-09-30a university or hospitalpast the reporting window
- NCT07242066completed2025-08-01a university or hospitalpast the reporting window
- NCT06374641completed2025-06-06a university or hospitalpast the reporting window
- NCT07506564completed2025-03-05a university or hospitalpast the reporting window
- NCT03596788terminated· Insufficient recruitment2025-02-17a university or hospitalpast the reporting window
- NCT04066569completed2024-10-30a university or hospitalpast the reporting window
- NCT04208256completed2024-09-30a university or hospitalpast the reporting window
- NCT05592951completed2023-07-14a university or hospitalpast the reporting window
- NCT05680064completed2023-07-01a university or hospitalpast the reporting window
- NCT04671043completed2023-02-02a university or hospitalpast the reporting window
- NCT04474002completed2022-12-31a university or hospitalpast the reporting window
Show the remaining 35Show the first 12
08 · the record
Sources
759
papers screened for aspartame
- admitted
- 5
- read and discarded
- 569
- not read yet
- 185
Sources cited
5 papers · 9 findings
Show every paper citedHide the papers cited
Other names · 11
1-methyl N-L-α-aspartyl-L-phenylalanate · 3-Amino-N-(α-carboxyphenethyl)succinamic acid N-methyl ester · 3-Amino-N-(α-methoxycarbonylphenethyl) succinamic acid · Asp-phe-ome · Aspartylphenylalanine methyl ester · E 951 · L-Aspartyl-L-phenylalanine methyl ester · NutraSweet
systematic · methyl L-α-aspartyl-L-phenylalaninate
sold as · AminoSweet · Sanecta