Papers/PMID:26247507
Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.
Journal of basic and clinical physiology and pharmacology2016The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
aspartame — increases total cholesterol (TC)
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.. - Study
- animal · not in humans
- Duration
- 2 months
- Dose
- 35 and 70 mg/kg daily by oral gavage
- Population
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.2016PMID:26247507Permalink
aspartame — increases triglycerides
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.. - Study
- animal · not in humans
- Duration
- 2 months
- Dose
- 35 and 70 mg/kg daily by oral gavage
- Population
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.2016PMID:26247507Permalink
aspartame — increases LDL cholesterol
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Also, ASP 2 and ASP 3 significantly increased the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the rats.”
Quoted verbatim from Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.. - Study
- animal · not in humans
- Duration
- 2 months
- Dose
- 35 and 70 mg/kg daily by oral gavage
- Population
- Male Wistar rats given aspartame 35 mg/kg (ASP 2) and 70 mg/kg (ASP 3) daily by oral gavage for 9 weeks versus distilled water; the 15 mg/kg dose is not covered by this sentence
Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats.2016PMID:26247507Permalink