Papers/PMID:27997218
Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2017The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
aspartame — increases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In our chronic in vivo model, we found that compared with the controls, serum TNF-α was increased in both chow + ASP and HFD + ASP groups (1622.3 ± 184.1 pg/mg of protein and 2512.1 ± 251.4 pg/mg of protein, respectively), indicating a higher level of systemic inflammation in groups receiving ASP.”
Quoted verbatim from Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- 0.96 mg/mL aspartame in drinking water
- Population
- Male C57BL/6 mice on chow or high-fat diet, aspartame in drinking water versus plain water for 18 weeks; serum collected at sacrifice
Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.2017PMID:27997218Permalink
aspartame — inhibits ALPI
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In the bowel loop model, IAP activity was significantly (p = 0.02) reduced in mice that had ASP instilled into the loops compared with saline controls (0.2 ± 0.03 vs 0.4 ± 0.24).”
Quoted verbatim from Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.. - Study
- animal · not in humans
- Dose
- 34 mg/kg instilled into the bowel loop
- Population
- Male mice, isolated 6-cm small-bowel loop injected with aspartame solution or saline, luminal contents assayed after 3 h
Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.2017PMID:27997218Permalink