Proteins/UNIPROT:Q9NR23

GDF3

ProteinUNIPROT:Q9NR23

Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO/Cripto..

Function from UniProtKB (Q9NR23), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

microphthalmia, isolated, with coloboma has a germline basis in GDF3DiseaseGenCC HGNC:4218|MONDO:0000170Inferred only

Statements

20 statements

20 statements · 3 reference databases · Subject: GDF3 · Sources: gene ontology, Hetionet, WikiPathways

Order

GDF3 covaries with C2CD3ProteinHetionet hetionet:covaries:26005-9573Inferred only
CIITA covaries with GDF3ProteinHetionet hetionet:covaries:4261-9573Inferred only
GDF3 covaries with CR2ProteinHetionet hetionet:covaries:1380-9573Inferred only
GALNT4 covaries with GDF3ProteinHetionet hetionet:covaries:8693-9573Inferred only
GTF3C1 covaries with GDF3ProteinHetionet hetionet:covaries:2975-9573Inferred only
HGSNAT covaries with GDF3ProteinHetionet hetionet:covaries:138050-9573Inferred only
IL17RB covaries with GDF3ProteinHetionet hetionet:covaries:55540-9573Inferred only
KIFC1 covaries with GDF3ProteinHetionet hetionet:covaries:3833-9573Inferred only
GDF3 covaries with NODALProteinHetionet hetionet:covaries:4838-9573Inferred only
NOL7 covaries with GDF3ProteinHetionet hetionet:covaries:51406-9573Inferred only
NYNRIN covaries with GDF3ProteinHetionet hetionet:covaries:57523-9573Inferred only
TAF1C covaries with GDF3ProteinHetionet hetionet:covaries:9013-9573Inferred only

Show the remaining 8

ZC3HAV1 covaries with GDF3ProteinHetionet hetionet:covaries:56829-9573Inferred only
GDF3 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
GDF3 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
GDF3 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
GDF3 regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q9NR23|GO:0030514Inferred only
GDF3 regulates negative regulation of epidermal cell differentiationBiological processgene ontology Q9NR23|GO:0045605Inferred only
GDF3 regulates positive regulation of fat cell differentiationBiological processgene ontology Q9NR23|GO:0045600Inferred only
GDF3 regulates regulation of cell fate commitmentBiological processgene ontology Q9NR23|GO:0010453Inferred only

Other names

2 names

Resolves to: GDF3

Also called: GDF-3Growth/differentiation factor 3

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