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Proteins/UNIPROT:O60895

RAMP2

Protein·UNIPROT:O60895

Open in the graph

Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP..

Function from UniProtKB (O60895), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

open-angle glaucoma has a germline basis in RAMP2DiseaseGenCC HGNC:9844|MONDO:0005338Inferred only

Statements

22 statements

22 statements · 4 reference databases · Subject: RAMP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CALCA interacts with RAMP2ProteinHetionet hetionet:interacts:10266-796Inferred only
CALCRL interacts with RAMP2ProteinHetionet hetionet:interacts:10203-10266Inferred only
SLC31A2 interacts with RAMP2ProteinHetionet hetionet:interacts:10266-1318Inferred only
VIPR1 interacts with RAMP2ProteinHetionet hetionet:interacts:10266-7433Inferred only
RAMP2 participates in Calcitonin-like ligand receptorsPathwayReactome R-HSA-419812Inferred only
RAMP2 participates in Cellular responses to mechanical stimuliPathwayReactome R-HSA-9855142Inferred only
RAMP2 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
RAMP2 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
RAMP2 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
RAMP2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
RAMP2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
RAMP2 participates in High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cellsPathwayReactome R-HSA-9856530Inferred only

Show the remaining 10

RAMP2 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
RAMP2 participates in Response of endothelial cells to shear stressPathwayReactome R-HSA-9860931Inferred only
RAMP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RAMP2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
RAMP2 regulates negative regulation of endothelial cell apoptotic processBiological processgene ontology O60895|GO:2000352Inferred only
RAMP2 regulates negative regulation of vascular permeabilityBiological processgene ontology O60895|GO:0043116Inferred only
RAMP2 regulates positive regulation of angiogenesisBiological processgene ontology O60895|GO:0045766Inferred only
RAMP2 regulates positive regulation of gene expressionBiological processgene ontology O60895|GO:0010628Inferred only
RAMP2 regulates regulation of blood pressureBiological processgene ontology O60895|GO:0008217Inferred only
RAMP2 regulates regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology O60895|GO:0008277Inferred only

Other names

2 names

Resolves to: RAMP2

Also called: Calcitonin-receptor-like receptor activity-modifying protein 2CRLR activity-modifying protein 2

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