Proteins/UNIPROT:P01282

VIP

ProteinUNIPROT:P01282

[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder..

[Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin..

[Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation..

Function from UniProtKB (P01282), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

24 statements

24 statements · 4 reference databases · Subject: VIP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ZNF300 covaries with VIPProteinHetionet hetionet:covaries:7432-91975Inferred only
DPP4 interacts with VIPProteinHetionet hetionet:interacts:1803-7432Inferred only
FAP interacts with VIPProteinHetionet hetionet:interacts:2191-7432Inferred only
MEOX2 interacts with VIPProteinHetionet hetionet:interacts:4223-7432Inferred only
MEP1A interacts with VIPProteinHetionet hetionet:interacts:4224-7432Inferred only
MME interacts with VIPProteinHetionet hetionet:interacts:4311-7432Inferred only
VIP interacts with PRICKLE1ProteinHetionet hetionet:interacts:144165-7432Inferred only
VIP interacts with UBQLN4ProteinHetionet hetionet:interacts:56893-7432Inferred only
VIP interacts with VIPR1ProteinHetionet hetionet:interacts:7432-7433Inferred only
VIP interacts with VIPR2ProteinHetionet hetionet:interacts:7432-7434Inferred only
VIP participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
VIP participates in Control of immune tolerance by vasoactive intestinal peptidePathwayWikiPathways WP4484Inferred only

Show the remaining 12

VIP participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
VIP participates in Gastric acid productionPathwayWikiPathways WP2596Inferred only
VIP participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
VIP participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
VIP participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
VIP participates in IL6 signalingPathwayWikiPathways WP364Inferred only
VIP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
VIP participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
VIP regulates positive regulation of cAMP/PKA signal transductionBiological processgene ontology P01282|GO:0141163Inferred only
VIP regulates positive regulation of cell population proliferationBiological processgene ontology P01282|GO:0008284Inferred only
VIP regulates positive regulation of protein catabolic processBiological processgene ontology P01282|GO:0045732Inferred only
VIP regulates regulation of protein localizationBiological processgene ontology P01282|GO:0032880Inferred only

Other names

6 names

Resolves to: VIP

Also called: ]Peptide histidine methioninamide 27Peptide histidine valine 42PHM-27PHV-42Vasoactive intestinal polypeptide

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