Proteins/UNIPROT:Q6ZRS2

SRCAP

ProteinUNIPROT:Q6ZRS2

Acts both as a chromatin remodeler and transcription coregulator. Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes expression through chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription..

Function from UniProtKB (Q6ZRS2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities has a germline basis in SRCAPDiseaseGenCC HGNC:16974|MONDO:0859202Inferred only
Floating-Harbor syndrome has a germline basis in SRCAPDiseaseGenCC HGNC:16974|MONDO:0007621Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: SRCAP · Sources: gene ontology, Hetionet, WikiPathways

Order

KLLN covaries with SRCAPProteinHetionet hetionet:covaries:100144748-10847Inferred only
PCDHB15 covaries with SRCAPProteinHetionet hetionet:covaries:10847-56121Inferred only
SRCAP covaries with RIOX1ProteinHetionet hetionet:covaries:10847-79697Inferred only
SRCAP covaries with ZNF26ProteinHetionet hetionet:covaries:10847-7574Inferred only
ZNF432 covaries with SRCAPProteinHetionet hetionet:covaries:10847-9668Inferred only
AR interacts with SRCAPProteinHetionet hetionet:interacts:10847-367Inferred only
SRCAP interacts with ATG9AProteinHetionet hetionet:interacts:10847-79065Inferred only
CARM1 interacts with SRCAPProteinHetionet hetionet:interacts:10498-10847Inferred only
CREBBP interacts with SRCAPProteinHetionet hetionet:interacts:10847-1387Inferred only
SRCAP interacts with DMAP1ProteinHetionet hetionet:interacts:10847-55929Inferred only
KAT2B interacts with SRCAPProteinHetionet hetionet:interacts:10847-8850Inferred only
NCOA2 interacts with SRCAPProteinHetionet hetionet:interacts:10499-10847Inferred only

Show the remaining 5

UBC interacts with SRCAPProteinHetionet hetionet:interacts:10847-7316Inferred only
SRCAP participates in Pathways affected in adenoid cystic carcinomaPathwayWikiPathways WP3651Inferred only
SRCAP participates in Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PathwayWikiPathways WP5565Inferred only
SRCAP regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q6ZRS2|GO:0045944Inferred only
SRCAP regulates regulation of DNA-templated transcriptionBiological processgene ontology Q6ZRS2|GO:0006355Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

3 names

Resolves to: SRCAP

Also called: Domino homolog 2KIAA0309Snf2-related CBP activator

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