Proteins/UNIPROT:Q8IUF8

RIOX2

ProteinUNIPROT:Q8IUF8

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles..

Function from UniProtKB (Q8IUF8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: RIOX2 · Sources: Hetionet, Reactome, UniProt

Order

APP interacts with RIOX2ProteinHetionet hetionet:interacts:351-84864Inferred only
UBC interacts with RIOX2ProteinHetionet hetionet:interacts:7316-84864Inferred only
RIOX2 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
RIOX2 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
RIOX2 participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
RIOX2 participates in HDMs demethylate histonesPathwayReactome R-HSA-3214842Inferred only
RIOX2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
RIOX2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
RIOX2 participates in Protein hydroxylationPathwayReactome R-HSA-9629569Inferred only
EGLN1 decreases the expression of RIOX2ProteinHetionet hetionet:regulates:54583-84864Inferred only
GRN increases the expression of RIOX2ProteinHetionet hetionet:regulates:2896-84864Inferred only
LOXL1 increases the expression of RIOX2ProteinHetionet hetionet:regulates:4016-84864Inferred only

Show the remaining 4

TP53 increases the expression of RIOX2ProteinHetionet hetionet:regulates:7157-84864Inferred only
VPS28 decreases the expression of RIOX2ProteinHetionet hetionet:regulates:51160-84864Inferred only
ZFX increases the expression of RIOX2ProteinHetionet hetionet:regulates:7543-84864Inferred only
RIOX2 requires the cofactor iron(2+)CompoundUniProt Q8IUF8Inferred only

Reactions

2 reactions

L-histidyl-[ribosomal protein uL15]+2-oxoglutarate(2-)+dioxygen(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15]+succinate(2-)+carbon dioxide
Catalysed by RIOX2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54024CC BY 4.0Reference data
L-histidyl-[protein]+2-oxoglutarate(2-)+dioxygen(3S)-3-hydroxy-L-histidyl-[protein]+succinate(2-)+carbon dioxide

Other names

12 names

Resolves to: RIOX2

Also called: 60S ribosomal protein L27a histidine hydroxylaseBifunctional lysine-specific demethylase and histidyl-hydroxylase MINAHistone lysine demethylase MINAMDIGMINAMINA53Mineral dust-induced gene proteinMYC-induced nuclear antigenNO52Nucleolar protein 52Ribosomal oxygenase MINAROX

← Every protein Find it in the graph →