Proteins/UNIPROT:Q04727

TLE4

ProteinUNIPROT:Q04727

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity)..

Function from UniProtKB (Q04727), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: TLE4 · Sources: gene ontology, Hetionet, Reactome

Order

CUX1 interacts with TLE4ProteinHetionet hetionet:interacts:1523-7091Inferred only
HDAC1 interacts with TLE4ProteinHetionet hetionet:interacts:3065-7091Inferred only
LIG4 interacts with TLE4ProteinHetionet hetionet:interacts:3981-7091Inferred only
MSX1 interacts with TLE4ProteinHetionet hetionet:interacts:4487-7091Inferred only
OTX1 interacts with TLE4ProteinHetionet hetionet:interacts:5013-7091Inferred only
OTX2 interacts with TLE4ProteinHetionet hetionet:interacts:5015-7091Inferred only
PAX5 interacts with TLE4ProteinHetionet hetionet:interacts:5079-7091Inferred only
POU2F2 interacts with TLE4ProteinHetionet hetionet:interacts:5452-7091Inferred only
TLE4 interacts with UBCProteinHetionet hetionet:interacts:7091-7316Inferred only
TLE4 participates in Deactivation of the beta-catenin transactivating complexPathwayReactome R-HSA-3769402Inferred only
TLE4 participates in Degradation of beta-catenin by the destruction complexPathwayReactome R-HSA-195253Inferred only
TLE4 participates in Formation of the beta-catenin:TCF transactivating complexPathwayReactome R-HSA-201722Inferred only

Show the remaining 15

TLE4 participates in NOTCH1 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-2122947Inferred only
TLE4 participates in Repression of WNT target genesPathwayReactome R-HSA-4641265Inferred only
TLE4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TLE4 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
TLE4 participates in Signaling by NOTCH1PathwayReactome R-HSA-1980143Inferred only
TLE4 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
TLE4 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
TLE4 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q04727|GO:0090090Inferred only
TLE4 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q04727|GO:0000122Inferred only
AKAP8L increases the expression of TLE4ProteinHetionet hetionet:regulates:26993-7091Inferred only
GRN decreases the expression of TLE4ProteinHetionet hetionet:regulates:2896-7091Inferred only
PIN1 decreases the expression of TLE4ProteinHetionet hetionet:regulates:5300-7091Inferred only
PPP2R3A increases the expression of TLE4ProteinHetionet hetionet:regulates:5523-7091Inferred only
RAB21 increases the expression of TLE4ProteinHetionet hetionet:regulates:23011-7091Inferred only
ZNF418 increases the expression of TLE4ProteinHetionet hetionet:regulates:147686-7091Inferred only

Other names

4 names

Resolves to: TLE4

Also called: Grg-4GRG4Groucho-related protein 4KIAA1261

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