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Proteins/UNIPROT:Q6P9F7
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition..
Function from UniProtKB (Q6P9F7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
55 statements
55 statements · 5 reference databases · Subject: LRRC8B · Sources: Bgee, Hetionet, Reactome, Rhea, WikiPathways
3 reactions
4 names
Resolves to: LRRC8B
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by SLC16A6 or LRRC8E or LRRC8B or LRRC8D or LRRC8A or LRRC8C
Reaction pageReversibleBalanced
Rhea RHEA:66328CC BY 4.0Reference data