FBXO24

Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation. Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition. Also mediates 'Lys-6'-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis (By similarity). Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity. In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells..

Function from UniProtKB (O75426), read 2026-09-23. CC BY 4.0.