NMUR1

G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum. Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation. In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (By similarity). Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity)..

Function from UniProtKB (Q9HB89), read 2026-09-23. CC BY 4.0.