Structure
Loading the model…
- Class
- Organic compound
- Formula
- C27H44O4
- Mass
- 432.645 g/mol
- Charge
- 0
- InChIKey
- WFZKUWGUJVKMHC-UKBUZQLGSA-N
- SMILES
- [H][C@@]12CC[C@]([H])([C@H](C)CC[C@@H](O)C(C)(C)O)[C@@]1(C)CCC/C2=CC=C1C[C@@H](O)C[C@H](O)C1=C
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
13 statements
13 statements · 2 reference databases · Subject: calcitetrol · Sources: Human-GEM, Rhea
- calcitetrol is converted to (1S)-1,25-dihydroxy-24-oxocalciolCompoundHuman-GEM MAR02143Inferred only
- calcitetrol is converted to (1S)-1,25-dihydroxy-24-oxocalciolCompoundHuman-GEM MAR02142Inferred only
- calcitriol is converted to calcitetrolCompoundHuman-GEM MAR02141Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR02139Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR02140Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR08006Inferred only
- calcitetrol is metabolised by CYP24A1ProteinRhea RHEA:24972Inferred only
- calcitetrol is metabolised by CYP2E1ProteinHuman-GEM MAR02143Inferred only
- calcitetrol is metabolised by CYP2E1ProteinHuman-GEM MAR02142Inferred only
- calcitetrol is metabolised by CYP4V2ProteinHuman-GEM MAR02143Inferred only
- calcitetrol is metabolised by CYP4V2ProteinHuman-GEM MAR02142Inferred only
- calcitetrol is a substrate of COQ6ProteinHuman-GEM MAR02142Inferred only
Show the remaining 1
- calcitetrol is a substrate of COQ6ProteinHuman-GEM MAR02143Inferred only
Reactions
9 reactions
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16cytosol
Human-GEM MAR02139CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02140CC BY 4.0Reference data
calcitriol+proton+NADPH(4-)+dioxygencalcitetrol+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02141CC BY 4.0Reference data
calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02142CC BY 4.0Reference data
calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02143CC BY 4.0Reference data
secalciferol+proton+NADPH(4-)+dioxygencalcitetrol+water+NADP(3-)
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR08006CC BY 4.0Reference data
calcitriol+2reduced [adrenodoxin]+dioxygen+2hydroncalcitetrol+2oxidized [adrenodoxin]+water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24964CC BY 4.0Reference data
calcitetrol+2reduced [adrenodoxin]+dioxygen+2hydron(1S)-1,25-dihydroxy-24-oxocalciol+2oxidized [adrenodoxin]+2water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24972CC BY 4.0Reference data
secalciferol+2reduced [adrenodoxin]+dioxygen+2hydroncalcitetrol+2oxidized [adrenodoxin]+water
Catalysed by CYP27B1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49064CC BY 4.0Reference data
Other names
7 names
Resolves to: calcitetrol
- Also called
- 1alpha,24R,25-trihydroxycholecalciferol1alpha,24R,25-trihydroxyvitamin D31alpha,24R,25(OH)3D31α,24R,25-trihydroxycholecalciferol1α,24R,25-trihydroxyvitamin D31α,24R,25(OH)3D3
- Systematic name
- (1S,3R,5Z,7E,24R,25)-9,10-secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol