Compound
secalciferol
A physiologically active metabolite of vitamin D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of calcitriol.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C27H44O3
- Mass
- 416.646 g/mol
- Charge
- 0
- InChIKey
- FCKJYANJHNLEEP-XRWYNYHCSA-N
- SMILES
- [H][C@@]12CC[C@]([H])([C@H](C)CC[C@@H](O)C(C)(C)O)[C@@]1(C)CCC/C2=CC=C1C[C@@H](O)CCC1=C
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
10 statements
10 statements · 2 reference databases · Subject: secalciferol · Sources: Human-GEM, Rhea
- calcidiol is converted to secalciferolCompoundHuman-GEM MAR02138Inferred only
- calcidiol is converted to secalciferolCompoundHuman-GEM MAR02137Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR02140Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR02139Inferred only
- secalciferol is converted to calcitetrolCompoundHuman-GEM MAR08006Inferred only
- secalciferol is metabolised by CYP24A1ProteinHuman-GEM MAR02139Inferred only
- secalciferol is metabolised by CYP24A1ProteinHuman-GEM MAR02140Inferred only
- secalciferol is metabolised by CYP24A1ProteinRhea RHEA:49196Inferred only
- secalciferol is metabolised by CYP24A1ProteinHuman-GEM MAR02767Inferred only
- secalciferol is metabolised by CYP27B1ProteinRhea RHEA:49064Inferred only
Reactions
12 reactions
calcidiol+proton+NADPH(4-)+dioxygensecalciferol+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16cytosol
Human-GEM MAR02137CC BY 4.0Reference data
calcidiol+proton+NADPH(4-)+dioxygensecalciferol+water+NADP(3-)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02138CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16cytosol
Human-GEM MAR02139CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygencalcitetrol+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 1.14.15.16mitochondrial matrix
Human-GEM MAR02140CC BY 4.0Reference data
secalciferol+proton+NADH(2-)+dioxygenMAM00607m+water+NAD(+)
Catalysed by CYP24A1
Reaction pageLeft to rightBalancedEC 3.4.24.16mitochondrial matrix
Human-GEM MAR02767CC BY 4.0Reference data
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR08000CC BY 4.0Reference data
secalciferol+proton+NADPH(4-)+dioxygencalcitetrol+water+NADP(3-)
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR08006CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08007CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09212CC BY 4.0Reference data
calcidiol+2reduced [adrenodoxin]+dioxygen+2hydronsecalciferol+2oxidized [adrenodoxin]+water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24968CC BY 4.0Reference data
secalciferol+2reduced [adrenodoxin]+dioxygen+2hydroncalcitetrol+2oxidized [adrenodoxin]+water
Catalysed by CYP27B1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49064CC BY 4.0Reference data
secalciferol+2reduced [adrenodoxin]+dioxygen+2hydron25-hydroxy-24-oxocalciol+2oxidized [adrenodoxin]+2water
Catalysed by CYP24A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49196CC BY 4.0Reference data
Other names
8 names
Resolves to: secalciferol
- Also called
- (24R)-24,25-dihydroxycholecalciferol(24R)-24,25-dihydroxyvitamin D3(5Z,7E)-(3S,24R)-9,10-seco-5,7,10(19)-cholestatriene-3,24,25-triol24(R),25-Dihydroxyvitamin D324R,25-dihydroxycholecalciferol24R,25-dihydroxyvitamin D324R,25(OH)2D3
- Systematic name
- (3S,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-3,24,25-triol