Proteins/UNIPROT:Q8IWE4

DCUN1D3

ProteinUNIPROT:Q8IWE4

Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation..

Function from UniProtKB (Q8IWE4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 3 reference databases · Subject: DCUN1D3 · Sources: gene ontology, Hetionet, Reactome

Order

CBLN2 covaries with DCUN1D3ProteinHetionet hetionet:covaries:123879-147381Inferred only
DIO3 covaries with DCUN1D3ProteinHetionet hetionet:covaries:123879-1735Inferred only
SNX21 covaries with DCUN1D3ProteinHetionet hetionet:covaries:123879-90203Inferred only
SOX14 covaries with DCUN1D3ProteinHetionet hetionet:covaries:123879-8403Inferred only
CUL1 interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-8454Inferred only
CUL2 interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-8453Inferred only
CUL3 interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-8452Inferred only
CUL4A interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-8451Inferred only
CUL5 interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-8065Inferred only
DCUN1D3 interacts with UBE2FProteinHetionet hetionet:interacts:123879-140739Inferred only
UBE2M interacts with DCUN1D3ProteinHetionet hetionet:interacts:123879-9040Inferred only
DCUN1D3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 9

DCUN1D3 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
DCUN1D3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DCUN1D3 regulates negative regulation of cell growthBiological processgene ontology Q8IWE4|GO:0030308Inferred only
DCUN1D3 regulates negative regulation of G1/S transition of mitotic cell cycleBiological processgene ontology Q8IWE4|GO:2000134Inferred only
DCUN1D3 regulates negative regulation of protein neddylationBiological processgene ontology Q8IWE4|GO:2000435Inferred only
DCUN1D3 regulates positive regulation of apoptotic processBiological processgene ontology Q8IWE4|GO:0043065Inferred only
DCUN1D3 regulates positive regulation of protein neddylationBiological processgene ontology Q8IWE4|GO:2000436Inferred only
DCUN1D3 regulates regulation of cell cycle processBiological processgene ontology Q8IWE4|GO:0010564Inferred only
DCUN1D3 regulates regulation of protein neddylationBiological processgene ontology Q8IWE4|GO:2000434Inferred only

Other names

5 names

Resolves to: DCUN1D3

Also called: DCNL3DCUN1 domain-containing protein 3Defective in cullin neddylation protein 1-like protein 3SCCRO3Squamous cell carcinoma-related oncogene 3

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