Proteins/UNIPROT:Q9NZN1

IL1RAPL1

ProteinUNIPROT:Q9NZN1Interleukin-1 receptor accessory protein-like 1

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)..

Function from UniProtKB (Q9NZN1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

intellectual disability, X-linked 21 has a germline basis in IL1RAPL1DiseaseGenCC HGNC:5996|MONDO:0010256Inferred only
non-syndromic X-linked intellectual disability has a germline basis in IL1RAPL1DiseaseGenCC HGNC:5996|MONDO:0019181Inferred only
X-linked complex neurodevelopmental disorder has a germline basis in IL1RAPL1DiseaseGenCC HGNC:5996|MONDO:0100148Inferred only

Statements

36 statements

36 statements · 4 reference databases · Subject: IL1RAPL1 · Sources: Bgee, gene ontology, Hetionet, Reactome

Order

IL1RAPL1 covaries with CBLN2ProteinHetionet hetionet:covaries:11141-147381Inferred only
CLEC2L covaries with IL1RAPL1ProteinHetionet hetionet:covaries:11141-154790Inferred only
IL1RAPL1 covaries with COX6A2ProteinHetionet hetionet:covaries:11141-1339Inferred only
IL1RAPL1 covaries with EHD2ProteinHetionet hetionet:covaries:11141-30846Inferred only
IL1RAPL1 covaries with FBXL19ProteinHetionet hetionet:covaries:11141-54620Inferred only
IL1RAPL1 covaries with KCTD5ProteinHetionet hetionet:covaries:11141-54442Inferred only
IL1RAPL1 covaries with LHFPL3ProteinHetionet hetionet:covaries:11141-375612Inferred only
IL1RAPL1 covaries with MEF2DProteinHetionet hetionet:covaries:11141-4209Inferred only
IL1RAPL1 covaries with MRGPRFProteinHetionet hetionet:covaries:11141-116535Inferred only
IL1RAPL1 covaries with SP7ProteinHetionet hetionet:covaries:11141-121340Inferred only
IL1RAPL1 covaries with SSNA1ProteinHetionet hetionet:covaries:11141-8636Inferred only
IL1RAPL1 covaries with TIMM13ProteinHetionet hetionet:covaries:11141-26517Inferred only

Show the remaining 24

IL1RAPL1 covaries with TRIM11ProteinHetionet hetionet:covaries:11141-81559Inferred only
IL1RAPL1 covaries with VANGL2ProteinHetionet hetionet:covaries:11141-57216Inferred only
IL1RAPL1 covaries with VWA1ProteinHetionet hetionet:covaries:11141-64856Inferred only
IL1RAPL1 covaries with XKR6ProteinHetionet hetionet:covaries:11141-286046Inferred only
IL1RAPL1 covaries with ZNF296ProteinHetionet hetionet:covaries:11141-162979Inferred only
IL1RAPL1 covaries with ZYXProteinHetionet hetionet:covaries:11141-7791Inferred only
IL1RAPL1 is expressed in buccal mucosa cellCell typeBgee ENSG00000169306Inferred only
CFTR interacts with IL1RAPL1ProteinHetionet hetionet:interacts:1080-11141Inferred only
CREB1 interacts with IL1RAPL1ProteinHetionet hetionet:interacts:11141-1385Inferred only
IL1RAPL1 interacts with NCS1ProteinHetionet hetionet:interacts:11141-23413Inferred only
IL1RAPL1 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL1RAPL1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL1RAPL1 participates in Interleukin-1 family signalingPathwayReactome R-HSA-446652Inferred only
IL1RAPL1 participates in Interleukin-38 signalingPathwayReactome R-HSA-9007892Inferred only
IL1RAPL1 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
IL1RAPL1 participates in Protein-protein interactions at synapsesPathwayReactome R-HSA-6794362Inferred only
IL1RAPL1 participates in Receptor-type tyrosine-protein phosphatasesPathwayReactome R-HSA-388844Inferred only
IL1RAPL1 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL1RAPL1 regulates negative regulation of exocytosisBiological processgene ontology Q9NZN1|GO:0045920Inferred only
IL1RAPL1 regulates positive regulation of dendritic spine morphogenesisBiological processgene ontology Q9NZN1|GO:0061003Inferred only
IL1RAPL1 regulates positive regulation of synapse assemblyBiological processgene ontology Q9NZN1|GO:0051965Inferred only
IL1RAPL1 regulates regulation of neuron projection developmentBiological processgene ontology Q9NZN1|GO:0010975Inferred only
IL1RAPL1 regulates regulation of postsynapse organizationBiological processgene ontology Q9NZN1|GO:0099175Inferred only
IL1RAPL1 regulates regulation of presynapse assemblyBiological processgene ontology Q9NZN1|GO:1905606Inferred only

Reactions

1 reaction

NAD(1-)+waterADP-D-ribose+nicotinamide+hydron
Catalysed by IL18RAP or IL1R1 or CD38 or IL1RL1 or BST1 or IL18R1 or SARM1 or IL1RL2 or IL1RAPL2 or IL1RAP or IL1RAPL1
Reaction pageLeft to rightBalanced
Rhea RHEA:16301

Other names

8 names

Resolves to: IL1RAPL1

Also called: IL-1-RAPL-1IL-1RAPL-1IL1RAPL-1Oligophrenin-4OPHN4Three immunoglobulin domain-containing IL-1 receptor-related 2TIGIRR-2X-linked interleukin-1 receptor accessory protein-like 1

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