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Proteins/UNIPROT:Q7Z2Z1
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation..
Function from UniProtKB (Q7Z2Z1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 3 reference databases · Subject: TICRR · Sources: gene ontology, Hetionet, Reactome
3 names
Resolves to: TICRR