Proteins/UNIPROT:Q5KU26

COLEC12

ProteinUNIPROT:Q5KU26

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease..

Function from UniProtKB (Q5KU26), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 3 reference databases · Subject: COLEC12 · Sources: Hetionet, Reactome, WikiPathways

Order

OR56A1 covaries with COLEC12ProteinHetionet hetionet:covaries:120796-81035Inferred only
APP interacts with COLEC12ProteinHetionet hetionet:interacts:351-81035Inferred only
EXOC1 interacts with COLEC12ProteinHetionet hetionet:interacts:55763-81035Inferred only
COLEC12 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
COLEC12 participates in Binding and Uptake of Ligands by Scavenger ReceptorsPathwayReactome R-HSA-2173782Inferred only
COLEC12 participates in Complement system in neuronal development and plasticityPathwayWikiPathways WP5090Inferred only
COLEC12 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
COLEC12 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
COLEC12 participates in Scavenging by Class A ReceptorsPathwayReactome R-HSA-3000480Inferred only
COLEC12 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

10 names

Resolves to: COLEC12

Also called: CL-P1CLP1Collectin placenta protein 1hCL-P1NSR2Nurse cell scavenger receptor 2SCARA4Scavenger receptor class A member 4Scavenger receptor with C-type lectinSRCL

← Every protein Find it in the graph →