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Proteins/UNIPROT:Q96PL1

SCGB3A2

Protein·UNIPROT:Q96PL1

Open in the graph

Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity)..

Function from UniProtKB (Q96PL1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

4 statements

4 statements · 2 reference databases · Subject: SCGB3A2 · Sources: Hetionet, Reactome

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MARCO interacts with SCGB3A2ProteinHetionet hetionet:interacts:117156-8685Inferred only
SCGB3A2 participates in Binding and Uptake of Ligands by Scavenger ReceptorsPathwayReactome R-HSA-2173782Inferred only
SCGB3A2 participates in Scavenging by Class A ReceptorsPathwayReactome R-HSA-3000480Inferred only
SCGB3A2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

5 names

Resolves to: SCGB3A2

Also called: Pneumo secretory protein 1PnSP-1PNSP1UGRP1Uteroglobin-related protein 1

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