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Reach

prostaglandin G2

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

329 compounds within 3 steps: 5 in 1, 66 in 2, 258 in 3

Does it reach a compound?

Three steps

7-oxolithocholateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. solute carrier organic anion transporter (chenodiol)
3. chenodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HSD17B10extracellular space, cytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by SLCO1B1, PTGS2extracellular space, cytosolOne of 3 routes
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by SLCO1B1, PTGS2extracellular space, cytosolOne of 3 routes
(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by SLCO1B1, PTGS2extracellular space, cytosol
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. Arachidonate: oxygen 11-oxidoreductase
Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
2. cystine to cysteine conversion
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SLCO2A1, MOCOSextracellular space, cytosolOne of 3 routes
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. unspecific monooxygenase (arachidonate)
Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 24 moreextracellular space, cytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. unspecific monooxygenase (arachidonate)
Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 3 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol
2-glyceryl-prostaglandin H2Reach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
11beta-prostaglandin F2Reach from here →
1. prostaglandin-endoperoxide synthase (prostaglandin G2)
2. prostaglandin-D synthase (prostaglandin H2)
3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)
Catalysed by PTGS1, PTGS2, HPGDS, PTGDS and 2 moreendoplasmic reticulum, cytosol
16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SLCO1B1, CYP3A7extracellular space, cytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SLCO1B1, CYP4F8extracellular space, cytosol
prostaglandin H1Reach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of prostaglandin E1 (cytosol to extracellular)
3. prostaglandin-E synthase (prostaglandin E1)
Catalysed by SLCO1B1, PTGES, PTGES3, PTGES2extracellular space, cytosolOne of 3 routes
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by SLCO1B1, ALOX15Bextracellular space, cytosol
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin G2 (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by SLCO1B1, ALOX15Bextracellular space, cytosol
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1

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