2,6,10,14-tetramethylpentadecanoate

Three steps

• octanedioyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Production of Suberylcarnitine

  Catalysed by SLC27A2, ACOT2, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by SLC27A2, ACOT2cytosol, peroxisomeOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by SLC27A2, ACOT2, CPT1A, CPT1C and 1 morecytosol, peroxisome

• (13Z)-eicosenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 5 routes

• tetradecanedioyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by SLC27A2, ACOT2, ACAA1, HSD17B4 and 2 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SLC27A2, ACOT2, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 2 routes

• undecanoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SLC27A2, ACOT2, ACSM4, ACSM1 and 4 morecytosol, peroxisomeOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 8 routes

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. fatty-acid-CoA ligase
  2. Peroxisomal Lumped Long Chain Fatty Acid Oxidation
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC27A2, ACOX3, ACAA1, HSD17B4 and 3 morecytosol, peroxisomeOne of 2 routes

• (3E)-decenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SLC27A2, ACOT2, ACADM, ECHS1 and 2 morecytosol, peroxisome, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SLC27A2, ACOT2, HADHA, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. fatty-acid-CoA ligase
  2. peroxisomal acyl-CoA thioesterase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC27A2, ACOT2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 4 routes