N-formyl-L-kynurenine

Three steps

• glycodeoxycholateReach from here →
  1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. Glycodeoxycholate amidohydrolase

  Catalysed by AFMID, KYAT3, AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by AFMID, KYAT3, AADAT, GLYATL2

• N-eicosanoylglycinateReach from here →
  1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by AFMID, KYAT3, AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by AFMID, KYAT3, AADAT, BAAT

• N-hexacosanoylglycineReach from here →
  1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by AFMID, KYAT3, AADAT, BAAT

• an N(2)-acyl-L-glutamineReach from here →
  1. L-tryptophan + O2 = N-formyl-L-kynurenine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by IDO1, TDO2, IDO2, SLC7A5 and 2 moreextracellular space, cytosol