N(1),N(12)-diacetylspermine

Three steps

• tetradecanedioyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1cytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. Production of Hexadecanedioylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. fatty-acid-CoA ligase

  Catalysed by SLC27A2cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACADM, ECHS1, ACAA2, HADHcytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. N1,N12-diacetylspermine to N1-acetylspermine conversion
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes