biliverdin IXalpha

Three steps

• glycolithocholate 3-sulfateReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-cysteinylglycineReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 6 morecytosol, extracellular spaceOne of 4 routes

• (R)-noradrenalineReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 4 routes

• thromboxane B2Reach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. Bilirubin:NAD+ oxidoreductase
  2. transport of bilirubin and GSH (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by BLVRB, BLVRA, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 4 routes