an N-acylsphing-4-enine 1-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

185 compounds within 3 steps: 1 in 1, 16 in 2, 168 in 3

Three steps

(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
(25R)-cholest-5-ene-3beta,26-diolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (25R)-cholest-5-ene-3beta,26-diol + 2 oxidized [adrenodoxin] + H2O
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(out) + cholesterol(in) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(in) + cholesterol(out)
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
(11Z,14Z)-eicosadienoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 4 moreGolgi apparatusOne of 3 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 5 moreGolgi apparatus
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 4 moreGolgi apparatus
a fatty acyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid
3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
Catalysed by PLPP1, PLPP3, PLPP2, NAAA and 6 more
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 4 moreGolgi apparatusOne of 3 routes
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGMS1 and 1 moreGolgi apparatusOne of 2 routes
a ganglioside GM4 (d18:1(4E))Reach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, UGT8 and 1 more
tricosanoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1lysosome, extracellular spaceOne of 12 routes
cholesteryl octadecanoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 3 moreOne of 2 routes
sphinga-4E,14Z-dienineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 4 moreGolgi apparatus
beta-D-glucosyl-(1<->1)-sphing-4-enineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
Catalysed by PLPP1, PLPP3, PLPP2, UGCG and 1 more
cholesteryl (9Z)-hexadecenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 moreOne of 2 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (8Z,11Z,14Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
(5Z)-tetradecenoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 moreOne of 2 routes
4beta-hydroxycholesterolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 4beta-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
an N(2)-acyl-L-glutamineReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 5 moreGolgi apparatus
(7Z)-hexadecenoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
cholesteryl (5Z,8Z,11Z)-eicosatrienoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
(6Z,9Z,12Z-octadecatrienoyl)-cholesterolReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
cholesteryl (11Z)-octadecenoateReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by PLPP1, PLPP3, PLPP2, GBA1 and 2 more
tricosanoyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 3 moreGolgi apparatus, cytosol
a 3-oxoacyl-CoAReach from here →
1. an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate
2. acyl-CoA:sphingosine N-acyltransferase
3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Catalysed by PLPP1, PLPP3, PLPP2, ASAH1 and 7 moreGolgi apparatus