L-histidine

Three steps

• 3-phenyllactateReach from here →
  1. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Formation of Phenyl-Lactate

  Catalysed by SLC7A8, GOT2, TATinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• prostaglandin G2Reach from here →
  1. L-histidine + H(+) = histamine + CO2
  2. transport of histamine (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by HDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• thio-Mo-molybdopterinReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycodeoxycholateReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. L-Arginine:glycine amidinotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. L-Arginine:glycine amidinotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-eicosanoylglycinateReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• N-docosanoylglycineReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• N-hexacosanoylglycineReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC25A2, SLC7A6, GLYATL1B, GLYATL1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• thromboxane B2Reach from here →
  1. L-histidine + H(+) = histamine + CO2
  2. transport of histamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by HDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. L-histidine + H(+) = histamine + CO2
  2. transport of histamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by HDC, SLCO1A2, SLCO1B3, SLC7A9extracellular space, cytosolOne of 4 routes