a fatty acid

Three steps

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LIPE, PLA2G4AOne of 2 routes

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. ATP:acylglycerol 3-phosphotransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by LIPE, AGKcytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. ATP:acylglycerol 3-phosphotransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by LIPE, AGKcytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. ATP:acylglycerol 3-phosphotransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by LIPE, AGKcytosol

• 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LIPE, PLA2G4A

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LIPE, PLA2G4A

• di-(9Z)-octadecenoylglycerolReach from here →
  1. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
  2. carboxylesterase (retinyl-ester)
  3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol

  Catalysed by RPE65, CES2, RBP4, LIPF and 17 morecytosol

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
  2. carboxylesterase (retinyl-ester)
  3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by RPE65, CES2, RBP4, LIPF and 18 morecytosol

• (11Z,14Z)-eicosadienoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• (17Z)-hexacosenoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol)Reach from here →
  1. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  3. an (R,S)-glycero-3-phospho-(3'-acyl-1'-glycerol) + a 1-acyl-sn-glycerol = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + glycerol

  Catalysed by ABHD11, PLD3, PLD4

• (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• 9-cis-retinolReach from here →
  1. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
  2. carboxylesterase (retinyl-ester)
  3. retinol binding protein (retinol)

  Catalysed by RPE65, CES2, RBP4, LIPF and 19 morecytosolOne of 3 routes

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ACSL3, LPGAT1, SGMS2, SAMD8

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ACSL3, CERS1, CERS6, CERS5 and 3 moreOne of 2 routes

• N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ACSL3, LPGAT1, SGMS2, SAMD8

• an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by ACSL3, LPGAT1, SGMS2, SAMD8

• tricosanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• 1,2-dihexadecanoyl-sn-glycerolReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by ACSL3, CERS1, CERS6, CERS3 and 4 more

• 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
  3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

  Catalysed by ACSL3, CERS1, CERS6, CERS3 and 5 more

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by ACSL3, LPGAT1, PLA2G15One of 2 routes