biocytin

Three steps

• pristanoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. fatty-acid-CoA ligase

  Catalysed by BTD, SLC27A2mitochondrial matrix, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by BTD, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 3 routes

• thio-Mo-molybdopterinReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by BTD, SLC7A6, MOCOSmitochondrial matrix, extracellular space, cytosol

• glycodeoxycholateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by BTD, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by BTD, ACADM, ECHS1, ACAA2 and 1 moremitochondrial matrix

• N-tetradecanoylglycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by BTD, SLC7A6, GLYATL2mitochondrial matrix, extracellular space, cytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by BTD, HADHA, ACAA2, HADHBmitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by BTD, SLC7A6, BAATmitochondrial matrix, extracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by BTD, SLC7A6, BAATmitochondrial matrix, extracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glycine and lysine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by BTD, SLC7A6, BAATmitochondrial matrix, extracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by BTD, SLC7A6, GLYATL1B, GLYATL1mitochondrial matrix, extracellular space, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. Biotinidase (Biotin), Mitochondrial
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by BTD, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes