pyridoxine

Three steps

• 3-hydroxy-L-kynurenineReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by PDXK, SCLY, KYNUcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PDXK, SCLY, AGXT2cytosol

• trans-4-hydroxy-L-prolineReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by PDXK, SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-prolineReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by PDXK, SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PDXK, SCLY, GGTLC3, GGT1 and 4 morecytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PDXK, SCLY, MOCOScytosol

• (2S)-2-aminobutanoateReach from here →
  1. ATP:pyridoxine 5'-phosphotransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by PDXK, SCLY, AGXT2cytosol