Papers/PMID:40886028
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.
Journal of health, population, and nutrition2025The record
8 findings · 1 compound · 8 endpoints · 2 null
What it reported
How to read these marksWhat moved
6 findings
Berberis vulgaris — decreases triglycerides
Evidence strength: moderate.Finding“The pooled analysis demonstrated that barberry supplementation significantly reduced TC (WMD = − 17.90 mg/dL; 95% CI: − 32.99 to − 2.81; p = 0.02; I2 = 90.9%; p < 0.001), LDL-C (WMD = − 11.38 mg/dL; 95% CI: − 21.35 to − 1.40; p = 0.025; I2 = 85.3%; p < 0.001), and TG (WMD = − 23.63 mg/dL; 95% CI: − 35.58 to − 11.68; p < 0.001; I2 = 55.7%; p = 0.027).”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -23.63 mean difference, 95% CI -35.58 to -11.68
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — decreases body mass
Evidence strength: moderate.Finding“The pooled analysis demonstrated a significant weight reduction (WMD = − 1.48 kg; 95% CI: − 2.94 to − 0.02; p = 0.047; I2 = 0.0%; p = 0.854), but not BMI (WMD = − 0.28 kg/m2; 95% CI: − 0.59 to 0.03; p = 0.079; I2 = 0.0%; p = 0.441) following barberry supplementation.”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -1.48 mean difference, 95% CI -2.94 to -0.02
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — decreases systolic blood pressure (setting unspecified)
Evidence strength: moderate.Finding“Analysis revealed that barberry supplementation significantly reduced both SBP and DBP, with pooled estimates showing a decrease of − 9.84 mmHg (95% CI: − 17.36 to − 2.31; p = 0.01; I2 = 85.6%; p < 0.001) for SBP and − 11.31 mmHg (95% CI: − 19.63 to − 3.00; p = 0.008; I2 = 93.2%; p < 0.001) for DBP.”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -9.84 mean difference, 95% CI -17.36 to -2.31
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — decreases diastolic blood pressure (setting unspecified)
Evidence strength: moderate.Finding“Analysis revealed that barberry supplementation significantly reduced both SBP and DBP, with pooled estimates showing a decrease of − 9.84 mmHg (95% CI: − 17.36 to − 2.31; p = 0.01; I2 = 85.6%; p < 0.001) for SBP and − 11.31 mmHg (95% CI: − 19.63 to − 3.00; p = 0.008; I2 = 93.2%; p < 0.001) for DBP.”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -11.31 mean difference, 95% CI -19.63 to -3
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — decreases total cholesterol (TC)
Evidence strength: moderate.Finding“The pooled analysis demonstrated that barberry supplementation significantly reduced TC (WMD = − 17.90 mg/dL; 95% CI: − 32.99 to − 2.81; p = 0.02; I2 = 90.9%; p < 0.001), LDL-C (WMD = − 11.38 mg/dL; 95% CI: − 21.35 to − 1.40; p = 0.025; I2 = 85.3%; p < 0.001), and TG (WMD = − 23.63 mg/dL; 95% CI: − 35.58 to − 11.68; p < 0.001; I2 = 55.7%; p = 0.027).”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -17.9 mean difference, 95% CI -32.99 to -2.81
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — decreases LDL cholesterol
Evidence strength: moderate.Finding“The pooled analysis demonstrated that barberry supplementation significantly reduced TC (WMD = − 17.90 mg/dL; 95% CI: − 32.99 to − 2.81; p = 0.02; I2 = 90.9%; p < 0.001), LDL-C (WMD = − 11.38 mg/dL; 95% CI: − 21.35 to − 1.40; p = 0.025; I2 = 85.3%; p < 0.001), and TG (WMD = − 23.63 mg/dL; 95% CI: − 35.58 to − 11.68; p < 0.001; I2 = 55.7%; p = 0.027).”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -11.38 mean difference, 95% CI -21.35 to -1.4
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
What did not
2 findings
Berberis vulgaris — no detected effect on body mass index
Evidence strength: moderate.FindingNull result“The pooled analysis demonstrated a significant weight reduction (WMD = − 1.48 kg; 95% CI: − 2.94 to − 0.02; p = 0.047; I2 = 0.0%; p = 0.854), but not BMI (WMD = − 0.28 kg/m2; 95% CI: − 0.59 to 0.03; p = 0.079; I2 = 0.0%; p = 0.441) following barberry supplementation.”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -0.28 mean difference, 95% CI -0.59 to 0.03
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink
Berberis vulgaris — no detected effect on glycated haemoglobin (HbA1c)
Evidence strength: moderate.FindingNull result“Barberry supplementation showed a significant effect on FBS (WMD = − 16.69 mg/dL; 95% CI: − 30.46 to − 2.93; p = 0.017; I2 = 96.6%; p < 0.001), HOMA-IR (WMD = − 0.95; 95% CI: − 1.79 to − 0.12; p = 0.025; I2 = 89.1%; p < 0.001), insulin (WMD = − 1.70 mU/L; 95% CI: − 2.33 to − 1.08; p < 0.001; I2 = 8.6%; p = 0.350), but not effect on HbA1c (WMD = − 0.72%; 95% CI: − 1.85 to 0.40; p = 0.209; I2 = 92.7%; p < 0.001).”
Quoted verbatim from The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 75 mg/day to 10 g/day fruit or supplement; 200 to 480 mL/day juice; 3 to 12 weeks
- Population
- Adults in randomized trials (T2DM, NAFLD, metabolic syndrome, benign breast disease, hypertension), all conducted in Iran; trials pooled barberry fruit/powder supplement and barberry juice against placebo or control
Effect -0.72 mean difference, 95% CI -1.85 to 0.4
The effect of barberry supplementation on components of metabolic syndrome: a grade assessment systematic review and meta-analysis of randomized controlled trials.2025PMID:4088602810.1186/s41043-025-01067-yPermalink